Well we are five pages into this thread and everyone else seems fine with the question. Why are you the only one having trouble?
Everyone's answer is an unambiguous "yes, of course you can, it's easy".
I'm the only one pointing out the elephant in the room, which is that there's nothing that anyone has suggested which could explain a circumstance under which it wouldn't be possible, and indeed easy, to run a popular D&D setting using D&D. That doesn't mean I'm "having trouble". It means that I'm asking a question which hasn't been answered yet, and which I note you have implicitly conceded has no answer.