Yeah.
There is a ****-ton of settings out there.
For 5e, I have used/ will soon be using:
Eberron, Midgard & it's Southlands (Kobold Press), Ptolus (MCG), Ravenloft, FR, Avernus, Underdark, Middle Earth (AiME) & Ruins of Symbaroum 5e.
Plus I am using Golarion soon for PF2E.
I will choose the...